The Cell Cycle and Cancer
I. Purpose
In this investigation you will explore the similarities and differences between the cell cycle of normal cells and cancer cells.
II. Background
The significance of normal cells is that cells can control their own growth but when they come in contact with other cells they respond by not growing and not dividing. Then, cancerous cells do not respond to the signals that regulate the growth of most cells they are placed in.
III. Hypothesis
I believe normal cell tissues will look different than cancerous cell tissue with regard to the phases of the cell cycle in that normal cells interphase might look different than cancerous interphase because normal cells which have to move around and cannot control their own growth because they're constantly moving around. If my hypothesis is correct I will see a greater percentage of cells dividing in normal tissue.
IV. Materials
- Cancerous Ovary Tissue
- Normal Ovary Tissue
- Cancerous Lung Tissue
- Normal Lung Tissue
- Cancerous Stomach Tissue
- Normal Stomach Tissue
V. Procedure
1. Click the monitor to watch the video about the cell cycle.
2. Now click the information button to learn about cancer.
3. Click on the microscope to begin learning about the phases of mitosis.
4. Click and drag the label to the corresponding cell under the microscope.
5.Open the data table and begin to record the number of cells in each phases of mitosis in the tissue sample. You can use the Calculator to determine the percentage of cells at rest. When you have counted all the cells in a particular sample, click the '"Tissues" slides and select a new sample. You can choose from normal or cancerous tissue.
6. Open the journal to answer some questions about cell division and cancer.
2. Now click the information button to learn about cancer.
3. Click on the microscope to begin learning about the phases of mitosis.
4. Click and drag the label to the corresponding cell under the microscope.
5.Open the data table and begin to record the number of cells in each phases of mitosis in the tissue sample. You can use the Calculator to determine the percentage of cells at rest. When you have counted all the cells in a particular sample, click the '"Tissues" slides and select a new sample. You can choose from normal or cancerous tissue.
6. Open the journal to answer some questions about cell division and cancer.
VI. Data
VII. Journal Questions
1. Basesd on the data I collected I can see that there are three more interphase cells in normal cells than cancerous. Also, regular cells are able to control there growth and are able to divide properly unlike cancerous cells which do not respond to the signals that regulate the growth of most cells.
2. I think normal lung will have the highest index ratio because in interphase there are 19/20 cells and when you divide them you get 95% which is the highest number from all of the tissues.
3. I think skin would have to have the highest mitosis index from the three samples because skin is exposed on the outside of your body so it needs to be protect from germs, viruses, etc.
2. I think normal lung will have the highest index ratio because in interphase there are 19/20 cells and when you divide them you get 95% which is the highest number from all of the tissues.
3. I think skin would have to have the highest mitosis index from the three samples because skin is exposed on the outside of your body so it needs to be protect from germs, viruses, etc.
VIII. Conclusion
In conclusion I believe normal cells tissue will look different than cancerous cell tissue with regard phases of the cell cycle in that normal cells interphase will look different than cancerous cells because normal cells can control their own cell growth. For example, normal cells have 5% diving while can cancerous has 80% dividing which means that normal cells have more at rest and are able to control themselves while cancerous only have 20% cells dividing which means that not many ells are able to rest. Then, I learned that normal lung has the most interphases cells compared to the other samples.Last, I also learned that skin has the most tissue compared to lung and muscle.